产品货号：
Z24567
中文名称：
PTRH2抗体
英文名称：
Anti-PTRH2 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PTRH2 Antibody |
| 指标别名 | BIT1;PTH2;CGI-147;BIT1;Peptidyl-tRNA hydrolase 2;mitochondrial;Bcl-2 inhibitor of transcription 1;PTH 2 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | PTRH2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Bit1 antibody was raised against a 16 amino acid synthetic peptide from near the center of human Bit1.The immunogen is located within amino acids 80 - 130 of Bit1. |
| 计算分子量 | 19kDa |
| 成分 | Bit1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | Bit1 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading.Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment.Bit1 (Bcl-2 inhibitor of transcription 1) was recently identified as being involved in this process.Bit1 is a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis where it forms a complex with AES,a small Groucho/transducin-like enhancer of split (TLE) protein and induces caspase-independent apoptosis.Both AES and TLE proteins are transcriptional co-repressors that play important roles in neurogenesis,segmentation,and sex determination.It has been suggested that Bit1-AES complexes turn off a survival-promoting gene transcription program controlled by TLE.Interestingly,apoptosis of cells transfected with Bit1 and AES could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins,and in particular,the alpha5beta1 integrin. |
| Uniprot ID | Q9Y3E5 |
| 基因名全称 | Peptidyl-tRNA hydrolase 2 |
| 蛋白名全称 | Peptidyl-tRNA hydrolase 2 |
| 推荐稀释比 | Bit1 antibody can be used for the detection of Bit1 by Western blot at 1 ～ 4μg/mL.Antibody can also be used for immunohistochemistry starting at 10μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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